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The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives.
Int J Mol Sci
December 2024
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Cancer cells undergo remarkable metabolic changes to meet their high energetic and biosynthetic demands. The Warburg effect is the most well-characterized metabolic alteration, driving cancer cells to catabolize glucose through aerobic glycolysis to promote proliferation. Another prominent metabolic hallmark of cancer cells is their increased reliance on glutamine to replenish tricarboxylic acid (TCA) cycle intermediates essential for ATP production, aspartate and fatty acid synthesis, and maintaining redox homeostasis.
View Article and Find Full Text PDFHydrolysis of the acetyl-CoA allosteric activator by Staphylococcus aureus pyruvate carboxylase.
Arch Biochem Biophys
December 2024
Department of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881, USA. Electronic address:
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to oxaloacetate which serves as an important anaplerotic reaction to replenish citric acid cycle intermediates. In most organisms, the PC-catalyzed reaction is allosterically activated by acetyl-coenzyme A. It has previously been reported that vertebrate PC can catalyze the hydrolysis of acetyl-CoA, offering a potential means for the enzyme to attenuate its allosteric activation.
View Article and Find Full Text PDFAnaplerotic filling in heart failure: a review of mechanism and potential therapeutics.
Cardiovasc Res
December 2024
Department of Cardiac Sciences and Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1.
Heart failure (HF) is a complex syndrome and a leading cause of mortality worldwide. While current medical treatment is based on known pathophysiology and is effective for many patients, the underlying cellular mechanisms are poorly understood. Energy deficiency is a characteristic of HF, marked by complex alterations in metabolism.
View Article and Find Full Text PDFOxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum.
PLoS Pathog
September 2024
Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Article Synopsis
- Anaplerosis is when certain enzymes help replace important molecules in a cycle that produces energy in cells.
- The enzyme pyruvate carboxylase (PYC) is important for this process and helps create a molecule called oxaloacetate.
- Researchers found that deleting the PYC1 gene in two types of fungi had different effects; for one type, it hurt its growth and ability to cause disease, while the other type was mostly unaffected.
Replenishment of TCA cycle intermediates and long-noncoding RNAs regulation in breast cancer.
Mol Cell Endocrinol
October 2024
Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. Electronic address:
The tricarboxylic acid (TCA) cycle is an essential interface that coordinates cellular metabolism and is as a primary route determining the fate of a variety of fuel sources, including glucose, fatty acid and glutamate. The crosstalk of nutrients replenished TCA cycle regulates breast cancer (BC) progression by changing substrate levels-induced epigenetic alterations, especially the methylation, acetylation, succinylation and lactylation. Long non-coding RNAs (lncRNA) have dual roles in inhibiting or promoting energy reprogramming, and so altering the metabolic flux of fuel sources to the TCA cycle, which may regulate epigenetic modifications at the cellular level of BC.
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