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-Lyophilized Fruit Extract Attenuated Acute Redox-Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephrotoxicity.
Pharmaceuticals (Basel)
January 2025
Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
Gentamicin (GM) administration is associated with decreased metabolism, increased oxidative stress, and induction of nephrotoxicity. L., containing flavonoids, anthocyanins, and phytosterols, possesses antioxidant and anti-inflammatory potential.
View Article and Find Full Text PDFAqueous Leaf Extract of Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers.
J Med Food
January 2025
Department of Biomedical sciences, Oklahoma State University Centre for Health and Science, Oklahoma, USA.
The effect of the aqueous extract of (AAI) on gentamicin (GEN)-induced kidney injury was investigated. The study involves 20 adult male Wistar rats (housed in four separate plastic cages) such that graded dosages of AAI were administered to the experimental group for 14 days per oral (PO) before exposure to GEN toxicity (100 mg/kg) for 1 week. At the end of the study, comparisons of some markers of renal functions, antioxidant status, and inflammatory and apoptotic markers were made between the control, GEN, and AAI-pretreated groups at < .
View Article and Find Full Text PDFThe potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.
J Ayurveda Integr Med
January 2025
Department of Pharmacy, Universitas Sriwijaya, South Sumatera, Indonesia.
Background: Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.
Objective: This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.
Protective Effects of Baicalein and Bergenin Against Gentamicin-Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study.
Basic Clin Pharmacol Toxicol
January 2025
Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Background: Drug-induced organ toxicity is a significant health concern, with gentamicin known for its effective antibacterial properties but also severe side effects, particularly cytotoxicity in liver and kidney tissues. This current study observed the preventive role of baicalein and bergenin against hepatic and renal injuries caused by gentamicin in rats.
Methods: Thirty-two male Sprague Dawley rats were divided into four groups, namely, control, gentamicin (gentamicin 80 mg/kg/day), baicalein (gentamicin 80 mg/kg/day + baicalein 100 mg/kg/day) and bergenin (gentamicin 80 mg/kg/day + bergenin 100 mg/kg/day).
Evaluation of hepatoprotective and nephroprotective activities of extract in rats.
Biomed Rep
February 2025
Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java 41361, Indonesia.
The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as have been proven effective in protecting the liver and kidneys from damage. Therefore, the present study aimed to examine the effect of extract (CcE) on paracetamol-induced hepatotoxicity and gentamicin-induced nephrotoxicity in rat model.
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