AI Article Synopsis
- A study found that adult patients with idiopathic thrombocytopenic purpura (ITP) had fewer circulating T gamma (suppressor) lymphocytes and fewer in the spleens of some patients.
- In patients who were cured by splenectomy, these reduced T gamma levels were not observed, while those still thrombocytopenic after surgery continued to show the abnormality.
- The normal levels of Tmu (helper) lymphocytes indicate an imbalance in T-cell types, which might play a role in the development of ITP, similar to what is seen in systemic lupus erythematosus.
Article Abstract
A significant reduction in the proportion and absolute number of circulating T gamma (suppressor) lymphocytes was observed in 15 adult patients with idiopathic thrombocytopenic purpura (ITP). The proportion of T gamma cells was also reduced in the spleen of four patients so investigated. This abnormality was not seen in 5 patients cured by splenectomy whilst it persisted in 3 who remained thrombocytopenic after splenectomy. The proportion of Tmu (helper) lymphocytes in ITP was normal. These findings, similar to those reported in systemic lupus erythematosus, suggest that an inbalance of the immunoregulatory T-cell subsets may be important in the pathogenesis of ITP.
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| http://dx.doi.org/10.1111/j.1600-0609.1981.tb01640.x | DOI Listing |
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