Interrelations between specialized cells, capillaries and intermediary cytofibrillar elements. 13. The fibrillar apparatus of the human dermis in some carcinomas of aged people.

The changes in the fibrillar apparatus (collagenous, elastic, reticulinic) during the development of some carcinomas in aged people were followed up in 70 fragments of human skin taken from adults and aged people suffering from senile keratosis (typical and with a tendency to malignancy) and skin carcinomas (basal cell and squamous cell carcinomas) and from the apparently healthy skin neighbouring carcinomas. Using the conventional microscopic field method, some previous morphological data were confirmed and new significant ones were reported. The changes were not always similar in intensity and direction in both layers of the dermis for each of the three varieties of fibers investigated. In skin carcinomas developed in aged people with senile keratosis there exists an inverse ratio between the richness of the fibrillar structure and the invasion and dissemination capacity of the tumours.