AI Article Synopsis
- The study provides evidence of specific calcium-binding sites in the cytomembrane system of skeletal muscle fibers, indicating their role in calcium accumulation at junctions between different membrane types.
- High calcium levels at these junctions may serve as "gate-locks," regulating intracellular calcium movement.
- Observations of openings in sarcoplasmic reticulum and T-tubules, along with similarities in enzyme reactions across various membrane structures, suggest continuity and developmental connections in muscle fiber membranes.
Article Abstract
In situ cytochemical evidence for specific Ca-binding sites in the cytomembrane system of skeletal muscle fibers is reported. High Ca accumulation was found at the junctions between different types of cytomembranes. Such junctions might represent "gate-locks" for intracellular Ca movements. Openings of sarcoplasmic reticulum (SR) in frog muscle fibers and of T-tubules in rat muscle fibers are described. Coated and noncoated caveolae were found in rat muscle fibers. The same positive reaction for TPP-ase was found in trans-Golgi zone, terminal cisternae and subsarcolemmal cisternae. These results suggest the membrane continuity and ontogenetic relationships in the cytomembrane system of skeletal muscle fibers.
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