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Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in from Seventh Pandemic.
Microorganisms
September 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206, China.
CTXΦ is a lysogenic filamentous phage that carries the genes encoding cholera toxin (), the main virulence factor of . The toxigenic conversion of environmental strains through CTXΦ lysogenic infection is crucial for the emergence of new pathogenic clones. A special allelic form of CTXΦ, called pre-CTXΦ, is a precursor of CTXΦ and without .
View Article and Find Full Text PDFConstruction and characterization of DNA libraries from cultured phages and environmental viromes.
Appl Environ Microbiol
October 2024
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Despite many efforts to understand and leverage the functional potential of environmental viromes, most bacteriophage genes are largely uncharacterized. To explore novel biology from uncultivated microbes like phages, metagenomics has emerged as a powerful tool to directly mine new genes without the need to culture the diverse microbiota and the viruses within. When a pure computational approach cannot infer gene function, it may be necessary to create a DNA library from environmental genomic DNA, followed by the screening of that library for a particular function.
View Article and Find Full Text PDFGene discovery from microbial gene libraries I: protection against reactive oxygen species-driven DNA damage.
Microbiol Spectr
November 2024
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Reactive oxygen species (ROS) pose a lethal risk for all life forms by causing damage to cell processes, genome-wide DNA damage-driving mutation, replicative instability, and death. Thus, the development of mechanisms to resist or repair ROS-induced DNA damage is critical for the reliable replication of nucleic acids. DNA repair and protection mechanisms have been discovered in all forms of life.
View Article and Find Full Text PDFInformation dynamics of in silico EEG Brain Waves: Insights into oscillations and functions.
PLoS Comput Biol
September 2024
Department of Electromagnetism and Physics of the Matter & Institute Carlos I for Theoretical and Computational Physics, University of Granada, Granada, Spain.
The relation between electroencephalography (EEG) rhythms, brain functions, and behavioral correlates is well-established. Some physiological mechanisms underlying rhythm generation are understood, enabling the replication of brain rhythms in silico. This offers a pathway to explore connections between neural oscillations and specific neuronal circuits, potentially yielding fundamental insights into the functional properties of brain waves.
View Article and Find Full Text PDFPhylogenetic Network Analyses Reveal the Influence of Transmission Clustering on the Spread of HIV Drug Resistance in Quebec from 2002 to 2022.
Viruses
July 2024
Primary HIV Infection (PHI) Cohort, Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Background: HIV drug resistance (HIV-DR) may jeopardize the benefit of antiretroviral therapy (ART) in treatment and prevention. This study utilized viral phylogenetics to resolve the influence of transmission networks on sustaining the spread of HIV-DR in Quebec spanning 2002 to 2022.
Methods: Time trends in acquired (ADR) and transmitted drug resistance (TDR) were delineated in treatment-experienced ( = 3500) and ART-naïve persons ( = 6011) with subtype B infections.
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