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Macrolactin A Is an Inhibitor of Protein Biosynthesis in Bacteria.

Biochimie

January 2025

Laboratory of Antimicrobial Resistance, Institute of Ecological and Agricultural Biology (X-BIO), Tyumen State University, Tyumen, Russia.

Macrolactin A (McA) is a secondary metabolite produced by Bacillus species. It has been known for its antimicrobial properties since the late 1980s, although the exact mechanism of its antibacterial activity remains unknown. In this study, we have found that McA is an inhibitor of protein synthesis in bacteria.

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Background: Seawater microbes (bacteria and archaea) play essential roles in coral reefs by facilitating nutrient cycling, energy transfer, and overall reef ecosystem functioning. However, environmental disturbances such as degraded water quality and marine heatwaves, can impact these vital functions as seawater microbial communities experience notable shifts in composition and function when exposed to stressors. This sensitivity highlights the potential of seawater microbes to be used as indicators of reef health.

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The contribution of the gut to the ingestion, production, absorption, and excretion of the extra ammonia and urea-N associated with feeding ("exogenous" fraction) has received limited prior attention. Analysis of commercial pellet food revealed appreciable concentrations of ammonia and urea-N. Long term satiation-feeding increased whole trout ammonia and urea-N excretion rates by 2.

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Nutrients in an aquatic system determine productivity, integrity and ecological status of the aquatic system. However, the excessive enrichment of these nutrients emanating from severe anthropogenic activity has substantially impacted water quality and biodiversity. There is diminutive information available on the water quality and trophic status of the northern Gulf of Lake Tana, Ethiopia due to accessibility difficulties.

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