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Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome.
Front Immunol
July 2022
Department of Cell Biology, Complutense University, Madrid, Spain.
MSCs products as well as their derived extracellular vesicles, are currently being explored as advanced biologics in cell-based therapies with high expectations for their clinical use in the next few years. In recent years, various strategies designed for improving the therapeutic potential of mesenchymal stromal cells (MSCs), including pre-conditioning for enhanced cytokine production, improved cell homing and strengthening of immunomodulatory properties, have been developed but the manufacture and handling of these cells for their use as advanced therapy medicinal products (ATMPs) remains insufficiently studied, and available data are mainly related to non-industrial processes. In the present article, we will review this topic, analyzing current information on the specific regulations, the selection of living donors as well as MSCs from different sources (bone marrow, adipose tissue, umbilical cord, etc.
View Article and Find Full Text PDFEngineered nanomaterials for (waste)water treatment - A scientometric assessment and sustainability aspects.
NanoImpact
April 2021
Department of Biology, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal; CESAM - Center of Environmental and Marine Studies & Department of Biology, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Application of nanomaterials for the treatment of effluents originated from various industrial and non-industrial sources, has been rapidly developed in recent decades. In this situation, there is a need for conclusive studies to identify the current status of the knowledge in this field and to promote the commercialization of such technologies by providing recommendations for future studies. In the present manuscript, a scientometric assessment on the progress made in this field has been performed and the results have been organized and discussed in terms of science statistics, research hotspots and trends, as well as the relevant sustainability aspects.
View Article and Find Full Text PDFConcept of sustainable waste management in the city of Zagreb: Towards the implementation of circular economy approach.
J Air Waste Manag Assoc
February 2017
c Croatian Agency for Environment and Nature , Zagreb , Croatia.
Unlabelled: Improvement of the current waste management is one of the main challenges for most municipalities in Croatia, mainly due to legal obligations set in different European Union (EU) directives regarding waste management, such as reduction of waste generation and landfilling, or increase of separately collected waste and recycling rates. This paper highlights the current waste management in the city of Zagreb by analyzing the waste generation, collection, and disposal scenario along with the regulatory and institutional framework. Since the present waste management system mainly depends upon landfilling, with the rate of separate waste collection and recycling far from being adequate, it is necessary to introduce a new system that will take into account the current situation in the city as well as the obligations imposed by the EU.
View Article and Find Full Text PDFMicroscopic observation of metal-containing particles from Chinese continental outflow observed from a non-industrial site.
Environ Sci Technol
August 2013
Environment Research Institute, Shandong University, Jinan, Shandong 250100, P R China.
Atmospheric metal-containing particles adversely affect human health because of their physiological toxicity. Mixing state, size, phase, aspect ratio, and sphericity of individual metal-containing particles collected in Hong Kong air in winter are examined through transmission electron microscopy (TEM). Eighteen percent of the sulfate particles have one or more tiny metal inclusions.
View Article and Find Full Text PDFThe relation between handedness indices and reproductive success in a non-industrial society.
PLoS One
December 2013
Behavioural Biology, Centre for Behaviour and Neuroscience, University of Groningen, Groningen, The Netherlands.
The evolution of handedness in human populations has intrigued scientists for decades. However, whether handedness really affects Darwinian fitness is unclear and not yet studied in a non-industrial society where selection pressures on health and handedness are likely to be similar to the situation in which handedness has evolved. We measured both hand preference and asymmetry of hand skill (speed of fine motor control, measured by a pegboard task, and accuracy of throwing), as they measure different aspects of handedness.
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