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Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.
J Inflamm Res
December 2024
Department of Traumatology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 40014, People's Republic of China.
Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. PANoptosis, a unique inflammatory programmed cell death, it manifests as the simultaneous activation of signaling markers for pyroptosis, apoptosis, and necroptosis. However, research on the role of PANoptosis in the development of IPF is currently limited.
View Article and Find Full Text PDFPrevalence of pseudopregnancy in bitch attending a veterinary teaching hospital in Spain.
Reprod Domest Anim
October 2024
Department of Animal Pathology, Universidad de Zaragoza, Zaragoza, Spain.
Article Synopsis
- Pseudopregnancy (PSG) in female dogs is a common condition, with a diagnosed prevalence of 30.81% among reproductive issues.
- The occurrence of PSG is influenced by seasonal oestrous cycles, with behavioral changes and physical symptoms like mammary enlargement appearing after the last heat cycle.
- Many cases resolve in about 16 days, which is longer than typical treatment recommendations, and the study suggests PSG may be underestimated due to owners not recognizing its signs, indicating a need for more research.
A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor.
Cell Rep
April 2024
McMaster University, Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, Hamilton, ON L8S 4L8, Canada. Electronic address:
In the search for much-needed new antibacterial chemical matter, a myriad of compounds have been reported in academic and pharmaceutical screening endeavors. Only a small fraction of these, however, are characterized with respect to mechanism of action (MOA). Here, we describe a pipeline that categorizes transcriptional responses to antibiotics and provides hypotheses for MOA.
View Article and Find Full Text PDFEvaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.
J Ethnopharmacol
March 2024
Department of Biosciences, Durham University, Durham, DH1 3LE, United Kingdom.
Ethnopharmacological Relevance: Melissa officinalis L. (Lamiaceae) is a medicinal plant native to Mediterranean regions and found in other parts of the world. Extracts and essential oil from this widely cultivated culinary medicinal herb are used in traditional medicine to manage a variety of disorders that include epilepsy and pain.
View Article and Find Full Text PDFMetergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen.
Neurotox Res
December 2023
The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.
Novel approaches are required to find new treatments for schizophrenia and other neuropsychiatric disorders. This study utilised a combination of in vitro transcriptomics and in silico analysis with the BROAD Institute's Connectivity Map to identify drugs that can be repurposed to treat psychiatric disorders. Human neuronal (NT2-N) cells were treated with a combination of atypical antipsychotic drugs commonly used to treat psychiatric disorders (such as schizophrenia, bipolar disorder, and major depressive disorder), and differential gene expression was analysed.
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