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How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center.
BMC Pregnancy Childbirth
January 2025
Reproductive Center of Shenzhen Zhongshan Obstetrics and Gynecology Hospital Formerly Reproductive Center of Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong Province, China.
Objective: To develop a predictive tool in the form of a Nomogram based on the Cox regression model, which incorporates the impact of the length of treatment cycles on the outcome of live birth, to evaluate the probability of infertile couples having a live birth after one or more complete cycles of In Vitro Fertilization (IVF), and to provide patients with a risk assessment that is easy to understand and visualize.
Methods: A retrospective study for establishing a prediction model was conducted in the reproductive center of Shenzhen Zhongshan Obstetrics & Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital). A total of 4413 patients who completed ovarian stimulation treatment and reached the trigger were involved.
Comprehensive transcriptomic analysis reveals turnip mosaic virus infection and its aphid vector Myzus persicae cause large changes in gene regulatory networks and co-transcription of alternative spliced mRNAs in Arabidopsis thaliana.
BMC Plant Biol
January 2025
Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, 77845, USA.
Background: Virus infection and herbivory can alter the expression of stress-responsive genes in plants. This study employed high-throughput transcriptomic and alternative splicing analysis to understand the separate and combined impacts on host gene expression in Arabidopsis thaliana by Myzus persicae (green peach aphid), and turnip mosaic virus (TuMV).
Results: By investigating changes in transcript abundance, the data shows that aphids feeding on virus infected plants intensify the number of differentially expressed stress responsive genes compared to challenge by individual stressors.
Full-length transcriptome analysis of male and female gonads in Japanese Eel (Anguilla japonica).
BMC Genomics
January 2025
State Key Laboratory of Mariculture Breeding; Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education；Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture and Rural Affairs, Fisheries College of Jimei University, Xiamen, 361021, China.
Background: The Japanese eel (Anguilla japonica) holds significant economic value in East Asia, but limitations in understanding its reproductive biology have hindered advancements in artificial breeding techniques. Previous research has primarily focused on conserved sex differentiation genes, offering limited insights into the broader molecular mechanisms driving gonadal development and sexual dimorphism. To address these limitations, this study aims to investigate key genes and pathways involved in gonadal development through a comprehensive transcriptomic analysis of male and female eel gonads.
View Article and Find Full Text PDFA study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis.
Sci Rep
January 2025
Department of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicine, Shanghai, China.
Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative stress status in rats with kidney stones through the brain-kidney axis. A rat model of kidney stones was established by administering 1% ethylene glycol and 2% ammonium chloride.
View Article and Find Full Text PDFMedication-related hospitalisations in patients with SLE.
Lupus Sci Med
January 2025
Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Objectives: Patients with SLE take multiple medications. Within a large prospective longitudinal SLE cohort, we characterised medication-related hospitalisations and their preventability.
Methods: We identified consecutive admissions to our tertiary hospitals between 2015 and 2020.
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