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Extractional spectrophotometric analysis of metronidazole, tinidazole, ornidazole and secnidazole bases through acid-dye complexation using bromothymol blue dye.
Pak J Pharm Sci
January 2012
Department of Pharmaceutical Chemistry, Suez Canal University, Ismailia, Egypt.
An easy, precise and valid extractional-spectrophotometric technique is described for the assessment of metronidazole (MNZ), tinidazole (TNZ), ornidazole (ONZ) and secnidazole (SNZ) in pure state and in their pharmaceutical formulations. The technique includes first the reduction of above cited drugs using HCl and zinc powder, then the formation of intense yellow colored ion-association complex species (1:3 drug/dye) using bromothymol blue (BTB) in a buffered aqueous acidic medium at pH 3-3.50.
View Article and Find Full Text PDFExtractional-spectrophotometric determination of famotidine in pharmaceutical formulations.
J Pharm Biomed Anal
November 1999
Chemistry Department, Faculty of Science, An-Najah National University, Nablus, Palestine.
The cationic dyes Remacrylblau B and Remacrylrot 2BL have been investigated as analytical reagents for the determination of anionic surfactants in waters. Extractional spectrophotometric procedures are proposed. The lowest quantity of anionic surfactant determinable (expressed as lauryl sulphate) when a 1-cm cell is used is 14 mug/l.
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