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ACS Pharmacol Transl Sci
January 2025
Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
This study presents a novel series of -acylated 1,2,4-triazol-5-amines and 1-pyrazol-5-amines, featuring a pyrazin-2-yl moiety, developed as covalent inhibitors of thrombin. These compounds demonstrated potent inhibitory activity, with derivatives and achieving IC values as low as 0.7 and 0.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.
The development of molecular species with switchable magnetic properties has been a long-standing challenge in chemistry. One approach involves binding an analyte, such as protons, to a compound to trigger a change in magnetism. Transition metal complexes have been targeted for this type of magnetic modulation because they can undergo changes in their spin states.
View Article and Find Full Text PDFChem Asian J
January 2025
Indian Institute of Technology Ropar, Chemistry, Nangal Road, 140001, Rupnagar, INDIA.
Carbon dioxide (CO2) capture and its subsequent catalytic fixation into usable compounds represent a potential approach for addressing the energy problem and the implications of global warming. Hence, it is necessary to develop effective catalytic systems required for the transformation of CO2 into valuable chemicals/fuels. Herein, we rationally designed a hydroxyl-functionalized porous organic framework (OH-POF) consisting of both acidic (OH) as well as basic N sites for the transformation of CO2 using epoxides for the production of cyclic carbonates (CCs), a useful commodity chemical under environmental-friendly, metal/solvent/co-catalyst-free conditions.
View Article and Find Full Text PDFBioorg Chem
January 2025
Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt.
The escalating prevalence of antibiotic-resistant bacteria has led to a serious global public health problem; therefore, there is an urgent need for the development of structurally innovative antibacterial agents. In our study, different series of tetra-substituted thiophene derivatives were designed and synthesized by multi-component reactions (MCRs) in moderate to excellent yields. Some of the designed final compounds were synthesized by both microwave assisted method and traditional synthesis.
View Article and Find Full Text PDFExp Neurobiol
December 2024
Department of Anatomy and Cell Biology, Dong-A University, College of Medicine, Busan 49201, Korea.
Peripheral neurodegenerative diseases induced by irreversible peripheral nerve degeneration (PND), such as diabetic peripheral neuropathy, have a high prevalence worldwide and reduce the quality of life. However, there is no agent effective against the irreversible PND. After peripheral nerve injury, Schwann cells play an important role in regulating PND.
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