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Prevalence of Aphthous Stomatitis: A Cross-Sectional Epidemiological Study.
Cureus
November 2023
Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Introduction Recurrent aphthous stomatitis (RAS) is a common ulcer of idiopathic etiology but is recurrent, causing painful ulcers in the non-keratinized mucosa. The disease is commonly seen in people aged 10-40 years. The etiology of RAS has yet to be well established, but several risk factors that lead to the development of RAS have been proven in the literature.
View Article and Find Full Text PDFAssociation of Surfactant Protein D Single Nucleotide Polymorphisms rs721917, rs2243639, rs3088308 with Recurrent Aphthous Stomatitis in Pakistani Population.
Genes (Basel)
May 2023
Department of Biomedical Sciences, King Edward Medical University, Lahore 54000, Pakistan.
Recurrent aphthous stomatitis (RAS) is a benign ulcerative condition, defined by the recurrent formation of non-contagious mucosal ulcers. Surfactant protein D (SP-D) is secreted frequently at surfaces exposed directly to body fluids. This study aims to investigate the association of SP-D single nucleotide polymorphisms (SNPs) with the onset of RAS.
View Article and Find Full Text PDFTriamcinolone acetonide release modelling from novel bilayer mucoadhesive films: an in vitro study.
Dent Mater
June 2023
Dental Physical Science Unit, Faculty of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Objectives: Recurrent aphthous stomatitis (RAS) is a painful disorder that commonly appears as ulcers on the oral mucosa, lasting ∼two weeks (minor) to months (major and herpetiform). Current treatment often necessitates the use of topical steroids in the form of pastes, mouthwashes, or gels, but these forms are often ineffective due to inadequate drug contact time with the ulcers. In this study, the performance of novel bilayer mucoadhesive buccal films loaded with triamcinolone acetonide (TA) has been evaluated for targeted drug delivery.
View Article and Find Full Text PDFRecurrent Aphthous Stomatitis: An Enigmatic Entity and Sign of Systemic Disease.
Indian J Dermatol
January 2022
Department of Dermatology and Pathology, Rutgers New Jersey Medical School, and Oral Medicine, Rutgers School of Dental Medicine, Newark, New Jersey, USA.
Recurrent aphthous stomatitis (RAS) is a common oral disease characterized by intermittent eruptions of painful oral ulcerations. Hippocrates first described aphthous stomatitis with the Greek word meaning "to inflame." RAS affects 10-20% of the population with the incidence being the highest among young adults.
View Article and Find Full Text PDFIL-10 and TGF-β1 gene polymorphisms in Greek patients with recurrent aphthous stomatitis.
Med Oral Patol Oral Cir Bucal
September 2022
Department of Oral Medicine and Pathology and Hospital Dentistry School of Dentistry, National and Kapodistrian University of Athens 2 Thivon St., Goudi 11527, Athens, Greece
Background: Recurrent aphthous stomatitis (RAS) is one of the most frequent inflammatory disorders of the oral mucosa. Cytokines, which play an important role in RAS pathogenesis, participate directly or indirectly in normal, immunological and inflammatory processes and are secreted from cells belonging to innate and adaptive immunity as a consequence of microbial and antigenic stimuli. Gene polymorphisms in specific cytokines may predispose to RAS development.
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