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| http://dx.doi.org/10.1136/bmj.289.6449.882 | DOI Listing |
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Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.
Curr Neuropharmacol
January 2025
Department of Pharmacology, School of Medicine University of Zagreb, Zagreb, Croatia.
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithemia. In hyperkalemia, BPC 157 demonstrated a comprehensive counteractive effect against KCl overdose (intraperitoneally, intragastrically, and in vitro), effectively mitigating symptoms such as muscular weakness, hypertension, sphincter dysfunction, arrhythmias, and lethality. It also counteracted the adverse effects of succinylcholine and magnesium overdose, including systemic muscle paralysis, arrhythmias, and hyperkalemia.
View Article and Find Full Text PDFThyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review.
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March 2025
Department of Emergency Medicine, The Fourth Affiliated hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China.
Hyperthyroidism is linked to several muscle disorders, including thyrotoxic myopathy, myasthenia gravis, and periodic paralysis. Thyrotoxic periodic paralysis (TPP) is a rare and potentially life-threatening neuromuscular condition that predominantly affects Asian males and is characterized by muscle weakness, hypokalemia, and thyrotoxicosis. Treatment involves potassium supplementation, and beta-blockers.
View Article and Find Full Text PDFSevere Hypokalemia and Respiratory Muscle Paralysis: An Atypical Manifestation of Primary Sjögren's Syndrome.
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Internal Medicine, Hospital de Santa Luzia - Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.
Primary Sjögren's syndrome (SS) is a systemic autoimmune disorder primarily affecting exocrine glands, that may occasionally present with severe extra-glandular manifestations. Although rarely, severe hypokalemia and respiratory muscle paralysis may be initial presentations. We report the case of a 33-year-old woman with a recent history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection who presented with headache and generalized muscle weakness.
View Article and Find Full Text PDFAirway Management of Hypokalaemic Paralysis with Trismus and Bulbar Palsy Due To Conn's Syndrome.
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Department of Anesthesia, Resuscitation and Pain Therapy, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain.
Severe Life-Threatening Hypokalemia Primarily Presented With Isolated Paralysis: Case Series From Ethiopia.
Clin Case Rep
January 2025
Nephrology Unit, Department of Internal Medicine, School of Health Sciences Addis Ababa University Addis Ababa Ethiopia.
Severe hypokalemia can primarily present as a weakness of the limbs, without any other clinical manifestation. A life-threatening level of decreased serum potassium level can be unusually present with isolated weakness of the limbs and might be misdiagnosed, or the diagnosis may be delayed.
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