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Improved Structure-Based Histidine p Prediction for pH-Responsive Protein Design.
J Chem Inf Model
January 2025
Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada.
The near neutral p of histidine is commonly exploited to engineer pH-sensitive biomolecules. For example, histidine mutations introduced in the complementarity-determining region (CDR) of therapeutic antibodies can enhance selectivity for antigens in the acidic microenvironment of solid tumors or increase dissociation rates in the acidic early endosomes of cells. While solvent-exposed histidines typically have a p near 6.
View Article and Find Full Text PDFUnloading damage evolution and rockburst risk assessment of Xuefengshan No.1 tunnel by combining multiple approaches.
Sci Rep
January 2025
College of Transportation Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Large-scale rock burst disasters often occur in high-stress and deep-buried tunnels, due to challenges in accurate forecasting and the lack of clarity regarding the underlying mechanisms largely. This study combined on-site stress drilling tests, coupled finite and discrete element simulations, and theoretical calculations to examine unloading damage, rockburst evolution, and deformation failure of the high-stress and deep-buried Xuefengshan No.1 tunnel.
View Article and Find Full Text PDFBuried or exposed kirschner wires in paediatric upper extremity fracture fixation: A systematic review and meta-analysis of infection rates and complications.
Injury
January 2025
Department of Trauma and Orthopaedic Surgery, University Hospitals Plymouth NHS Trust, Derriford Hospital, Derriford Road, Plymouth, Devon, PL6 8DH, United Kingdom. Electronic address:
Background: Paediatric upper limb fractures are commonly treated with Kirschner (K) wire fixation, which can be buried or left exposed. Although both techniques are widely used, controversy remains regarding infection risk, complications, and other clinical outcomes between buried and exposed K-wires. This systematic review and meta-analysis aimed to compare infection rates and secondary outcomes between buried and exposed K-wires in paediatric upper limb fractures located distal to and including the elbow, and proximal to the carpus.
View Article and Find Full Text PDFColorimetric Xylenol Orange: A Long-Buried Aggregation-Induced Emission Dye and Restricted Rotation for Dual-Mode Sensing of pH and Metal Ions.
Anal Chem
January 2025
Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
As the third largest class of dyes in the world, triphenylmethane dyes are widely applied in colorimetric sensing. However, triphenylmethane dyes are commonly nonfluorescent, which limits their sensing applications. It is worthwhile to study the fluorescence off/on control of triphenylmethane dyes and promote the applications of triphenylmethane dyes in sensing technology.
View Article and Find Full Text PDFResearch on spatial prediction technology for mitigating tunnel inrush disasters under complex geological conditions in China's Hengduan Mountain Range.
Sci Rep
January 2025
Chengdu Engineering Corporation Limited, Chengdu, 610072, China.
The proportion of railway high-altitude buried tunnels in complex and dangerous mountainous areas in southwest China is exceptionally high. With the characteristics of suddenness, intermittency, instantaneousness, and destruction, inrushinrushing and collapse is one of the main risks in the tunnel construction process. Therefore, in the design and construction process of tunnels in Hengduan Mountain area, it is very important to identify the mechanism of sudden s inrushing and collapse risks, predict the spatial location and scale of possible inrushing and collapse, and formulate corresponding tunnel design and construction response measures.
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