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Determination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau.
ACS Chem Neurosci
January 2025
Department of Chemistry, University of California, Riverside, California 92521, United States.
Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins.
View Article and Find Full Text PDFBackground: Anorexia nervosa has the highest mortality rate of any psychiatric disorder, and purging behaviors can cause a fatal electrolyte and acid-base imbalance. Routine laboratory testing during inpatient care is essential because these patients often provide inaccurate information about their diet and purging behaviors. However, blood gas analysis for an acid-base evaluation is rarely performed in the psychiatric setting because psychiatrists are not accustomed to evaluating the results.
View Article and Find Full Text PDFAn Active-Site Bro̷nsted Acid-Base Catalyst Destabilizes Mandelate Racemase and Related Subgroup Enzymes: Implications for Catalysis.
Biochemistry
January 2025
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction, i.e., the metal-assisted, Bro̷nsted base-catalyzed abstraction of the α-proton from a carboxylate substrate to form an enol(ate) intermediate.
View Article and Find Full Text PDFRetrospective evaluation of acid-base analysis in dogs and cats with diabetic ketosis (2017-2021): 96 cases.
J Vet Emerg Crit Care (San Antonio)
January 2025
Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Objective: To describe the acid-base balance of diabetic animals with ketosis and to identify underlying mechanisms of acid-base changes using semiquantitative analysis.
Design: Retrospective study.
Setting: University teaching hospital.
Application of digital-movie-based flow colorimetry to hue-based end point detection of acid-base titration by feedback-based flow ratiometry using universal indicator.
Anal Sci
January 2025
Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima, 770-8505, Japan.
A digital-movie-based flow colorimetry for pH measurement using a universal indicator has been applied to the end point detection of acid-base titrations. A two-channel flow system of feedback-based flow ratiometry, primarily consisting of two peristaltic pumps, a digital microscope-based detector, and a laptop computer, was constructed; a Visual Basic.NET program written in-house was used for automating the analytical processes.
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