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| http://dx.doi.org/10.1136/bmj.289.6444.532 | DOI Listing |
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Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data.
J Intensive Care
December 2024
The University of Alabama at Birmingham, Birmingham, AL, USA.
Background: Fluid balance gap (FBgap-prescribed vs. achieved) is associated with hospital mortality. Downtime is an important quality indicator for the delivery of continuous renal replacement therapy (CRRT).
View Article and Find Full Text PDFDetermining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol.
BMJ Open
December 2024
Department of Physiology, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
Introduction: Male infertility, defined as the inability to impregnate a fertile female, arises from various factors, among which sperm motility plays a pivotal role in determining reproductive potential. Seminal plasma, a complex fluid comprising diverse proteins, serves to nourish and support sperm, thereby facilitating their function within the female reproductive tract for successful conception. Normozoospermia denotes normal sperm motility in males, whereas asthenozoospermia indicates reduced sperm motility.
View Article and Find Full Text PDFAssessment of Brain Development in Children With Congenital Diaphragmatic Hernia - an Automated Brain Segmentation Approach.
In Vivo
December 2024
Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Background/aim: Congenital diaphragmatic hernia (CDH) is a critical condition affecting newborns, which often results in long-term morbidities, including neurodevelopmental delays, which affect cognitive, motor, and behavioral functions. These delays are believed to stem from prenatal and postnatal factors, such as impaired lung development and chronic hypoxia, which disrupt normal brain growth. Understanding the underlying mechanisms of these neurodevelopmental impairments is crucial for improving prognosis and patient outcomes, particularly as advances in treatments like ECMO have increased survival rates but also pose additional risks for neurodevelopment.
View Article and Find Full Text PDFEarly Oral Feeding in Patients Undergoing Upper Gastrointestinal Surgery: A Propensity Score-matching Study.
In Vivo
December 2024
Department of Surgery, Clinical Center, Medical School, University of Pécs, Pécs, Hungary.
Background/aim: Enhanced recovery after surgery (ERAS) protocol is adopted in clinical practice worldwide, but a lack of evidence for measurable benefits after upper gastrointestinal (GI) surgeries can be detected especially regarding early oral feeding.
Patients And Methods: A propensity score-matching study was conducted at the Department of Surgery of the University of Pécs between January 2020 and December 2023. The study included patients who underwent upper GI cancer surgery and were treated according to an early oral feeding protocol (EOF).
Six Versus Three Doses of Intrapleural Streptokinase in Childhood Empyema: A Randomized Controlled Trial.
Pediatr Pulmonol
December 2024
Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Objective: To compare the efficacy and safety of administering six doses of intrapleural streptokinase (SK) versus the conventional three doses, in children with empyema.
Study Design: In this open label, placebo-controlled, randomized trial, we enrolled 53 children with empyema, who received three doses of intrapleural SK. Thereafter, those without clinical improvement (n = 34) and those showing clinical improvement but having persistent pleural fluid width > 10 mm on chest ultrasonography (n = 13), were randomized to receive three additional doses of SK, or three doses of placebo (normal saline).
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