AI Article Synopsis
- The study examined how different hormone treatments (estrogen and estrogen-progesterone) affect the levels and composition of glycosaminoglycans in the aorta of ovariectomized rabbits.
- Results showed that both hormone treatments significantly increased the levels of glycosaminoglycans, particularly dermatan sulfate and chondroitin sulfates, while decreasing hyaluronic acid and heparan sulfate.
- These changes in glycosaminoglycan composition are considered to contribute to the anti-atherosclerotic effects of female hormones.
Article Abstract
Intima-media of thoracic aortas obtained from estrogen-treated, estrogen-progesterone-treated and sham-treated ovariectomized rabbits were separately digested with pronase after extraction of fat. Glycosaminoglycan fractions were then separated from the resulting glycoconjugate fractions by precipitation with cetylpyridinium chloride. The glycosaminoglycan levels increased after treatments with estrogen and estrogen-progesterone. Glycosaminoglycan compositions were determined by sequential digestion with Streptomyces hyaluronidase, chondroitinase AC, chondroitinase ABC and heparitinase 1. The proportions of dermatan sulfate and chondroitin sulfates AC increased after treatments with these hormones, while those of hyaluronic acid and heparan sulfate decreased. The changes of the proportions of dermatan sulfate and hyaluronic acid were dramatic. The changes of the glycosaminoglycan compositions with these hormones are thought to be an anti-atherosclerotic effect of these female hormones.
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| http://dx.doi.org/10.1620/tjem.143.113 | DOI Listing |
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