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Follicular lymphoma (FL) is a gradually progressing type of B-cell non-Hodgkin lymphoma (NHL), distinguished by its characteristic follicular pattern of growth and a typically indolent clinical course. It is identified by the abnormal growth of B-cells in the lymph nodes. We report a case of a 45-year-old female who came up with complaints of heavy menstrual bleeding and easy fatiguability.

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Follicular lymphoma is a relatively indolent B-cell lymphoma composed of neoplastic centrocytes and centroblasts. The histologic transformation of follicular lymphoma is a well-described phenomenon with an average risk of 30% at ten years. The occurrence of Hodgkin lymphoma after follicular lymphoma, as well as composite lymphoma, is extremely rare.

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Background: Follicular lymphoma (FL) is characterized by t(14;18)(q32;q21) involving the IGH and BCL2 genes. However, 10-15% of FLs lack the BCL2 rearrangement. These BCL2-rearrangement-negative FLs are clinically, pathologically, and genetically heterogeneous.

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A study of criteria for grading follicular lymphoma using a cell type classifier from pathology images based on complementary-label learning.

Micron

September 2024

Dapartment of Computer Science, Gokiso-cho, Showa-ku, Nagoya-shi, Aichi 466-8555, Japan. Electronic address:

Article Synopsis
  • The study suggests a new grading criterion for follicular lymphoma that aligns more closely with pathologists' evaluations than the current World Health Organization (WHO) criteria.
  • Due to the difficulty in manually counting and identifying cell types like centroblasts and centrocytes, they utilize digital pathology and image processing for accurate cell classification.
  • A new dataset is created to assist in building a cell type classifier, which shows improved consistency with pathologist findings compared to the WHO standards.
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[Diagnosis and differential diagnosis of large B-cell lymphoma with IRF4 rearrangement].

Zhonghua Bing Li Xue Za Zhi

June 2024

Department of Pathology, Xuzhou Medical University;Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.

To analyze the clinicopathological features and differential diagnosis of large B-cell lymphoma with IRF4 rearrangement, aiming enhance its recognition and prevent misdiagnosis. The clinicopathological features, immunophenotype, and fluorescence in situ hybridization (FISH) results of six cases diagnosed with IRF4 rearrangement-positive B-cell lymphoma at the Affiliated Hospital of Xuzhou Medical University from 2015 to 2023 were retrospectively analyzed. Additionally, a comprehensive review of the literature was conducted.

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