AI Article Synopsis
- A woman with multicentric reticulohistiocytosis experienced bleeding and had low factor VIII levels, leading to a pharmacological test involving an i.v. infusion of DDAVP.
- The test aimed to assess how well her body could release factor VIII-related properties from storage sites.
- Results indicated she had a weaker response to DDAVP compared to a normal control, suggesting possible issues either with the release mechanism or with the production/storage of factor VIII in her body.
Article Abstract
A woman with multicentric reticulohistiocytosis, having symptoms including bleeding and a borderline level of factor VIII, was given an i.v. infusion of DDAVP as a pharmacological test to evaluate the release of factor VIII-related properties from storage sites. The results show a reduced response to DDAVP in the patient in comparison with a normal control subject. This could be due either to a defect in the release of the factor VIII complex after DDAVP or to a reduced synthesis and/or storage capacity by the storage cells.
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| http://dx.doi.org/10.1007/BF02905038 | DOI Listing |
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