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Article Synopsis
- The case report details a rare occurrence of a postpubertal-type teratoma in a 48-year-old male, which appeared as a late recurrence of a previously diagnosed seminoma following testicular surgery six years earlier.
- Imaging tests showed a retroperitoneal tumor with unusual characteristics, leading to a biopsy that indicated a high-grade malignant tumor, prompting neoadjuvant chemotherapy that helped shrink the tumor before surgical removal.
- Further analysis revealed that the original seminoma diagnosis overlooked a mixed germ cell tumor component, underscoring the need for comprehensive histological evaluations in testicular germ cell tumors to better inform prognosis and treatment options.
High-dose chemotherapy with autologous stem cell transplants in adult primary non-seminoma mediastinal germ-cell tumors. A report from the Cellular Therapy and Immunobiology working party of the EBMT.
ESMO Open
September 2024
Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.
Article Synopsis
- Primary mediastinal germ-cell tumors (PMGCTs) represent a small percentage of all germ-cell tumors, notably having a poorer prognosis compared to gonadal tumors, with low overall survival rates especially in cases with metastases.
- A retrospective study assessed the effectiveness of high-dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) for treating 69 adult male patients with primary mediastinal non-seminoma germ cell tumors (PMNSGCT), primarily using carboplatin/etoposide.
- Results showed that upfront HDC significantly improved progression-free survival and overall survival rates, with a 2-year overall survival rate of 43.3% for the cohort, while identifying predictors for better
A 29-year-old male presented with acute left-sided weakness in both the upper extremity (UE) and lower extremity (LE), an atypical symptom for testicular cancer but not uncommon for brain metastasis. Testicular cancer usually manifests as a testicular mass or discomfort. His medical history included a previously resected testicular mass, with pathology results unknown due to the patient being lost to follow-up.
View Article and Find Full Text PDFTeratoma to Angiosarcoma: A Metamorphosis in the Mediastinum.
Cureus
June 2024
Pulmonary and Critical Care Medicine, Staten Island University Hospital, Staten Island, USA.
We describe a rare and remarkable transformation of an immature mediastinal teratoma into high-grade angiosarcoma in a 21-year-old male. Mediastinal teratomas, particularly immature ones, are exceedingly rare, representing a small fraction of germ cell tumors (GCTs). Our case describes the clinical journey of the patient, who initially presented with acute chest pain and was subsequently diagnosed with an immature teratoma following imaging studies and elevated tumor markers.
View Article and Find Full Text PDFPrimary retroperitoneal lymph node dissection for metastatic non-seminomatous germ cell tumours: outcomes and adjuvant chemotherapy.
BJU Int
October 2024
Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Objectives: To compare the outcomes and treatment burden of primary retroperitoneal lymph node dissection (pRPLND) alone versus pRPLND + adjuvant chemotherapy (AC) in patients with pathological stage II (PSII) non-seminomatous germ cell tumours (NSGCT).
Patients And Methods: Retrospective review of the Princess Margaret Cancer Center eTestes cancer database identified patients with PSII NSGCT after pRPLND between 1995 and 2020. The primary outcome was relapse-free survival (RFS).
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