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Paget's disease of bone occurs in elderly people and resembles no other disease. The most frequent diagnostic errors are made when it is discovered in young adults, especially after an injury. Forms with osteolysis of the lower limbs are the most misleading, and it is better to avoid biopsies in such cases, as they may be followed by fractures.

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The authors report three unusual cases of paediatric osteomyelitis resembling a lytic or mixed osteosarcoma. The severity of the radiological lesions is such that only a diagnostic approach is possible before surgical biopsy. Under the effects of treatment, osteolysis resolved in two cases by bone eburnation in two cases and pandiaphyseal sequestration in one case.

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