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Circadian rhythm and lithium response in bipolar disorder: Insights from actigraphy and NR1D1 polymorphism.
Chronobiol Int
January 2025
Department of Child and Adolescent Psychiatry, Balıkesir Atatürk City Hospital, Balıkesir, Turkey.
Lithium has long been used as a cornerstone mood stabilizer in the treatment of bipolar disorder (BD). However, reliable biomarkers that can predict which patients will respond better to lithium are still lacking. This study aims to evaluate the potential of NR1D1 gene SNP; rs2071427 and actigraphic measurements in predicting lithium response.
View Article and Find Full Text PDFValproate, a widely utilized medication for epilepsy, mood disorders, and migraines, has attracted attention for its potential therapeutic benefits extending beyond its traditional uses. This review article compiles recent findings on the expanded utility of valproate outside of epilepsy, mood disorders, and migraines. The review acknowledges conflicting results, discusses opportunities for future research, and underlines both well-established and lesser-known adverse effects, along with possible interventions to mitigate these side effects.
View Article and Find Full Text PDFSynergistic Modulation of Solid- and Cathode-Electrolyte Interphase via a Lithium Salt Additive toward Stable Sodium Metal Batteries.
Nano Lett
January 2025
Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang 315200, P. R. China.
Constructing feasible sodium metal batteries (SMBs) faces complex challenges in stabilizing cathodes and sodium metal anodes. It is imperative, but often underemphasized, to simultaneously regulate the solid-electrolyte interphase (SEI) to counter dendrite growth and the cathode-electrolyte interphase (CEI) to mitigate cathode deterioration. Herein, we introduce lithium 2-trifluoromethyl-4,5-dicyanoimidazolide (LiTDI) as an efficacious additive in a carbonate-based electrolyte to extend cycle lifespan of full SMBs: the capacity retention reaches 77.
View Article and Find Full Text PDFEffects of lithium carbonate combined with olanzapine on glucose and lipid metabolism in the treatment of bipolar disorder and gender differences.
Pak J Pharm Sci
January 2025
Department of Psychiatry, the Fifth People's Hospital of Luoyang, Luoyang City, Henan Province.
To explore the effect of lithium carbonate combined with olanzapine on glucose and lipid metabolism, as well as gender differences in treating bipolar disorder (BD). 110 BD patients admitted to the Fifth People's Hospital of Luoyang from February 2022 to January 2024 were retrospectively included in the study. Patients were categorized into two groups based on treatment: The single group (lithium carbonate, n = 50) and the coalition group (lithium carbonate + olanzapine, n=60).
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