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Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes).
Mar Pollut Bull
October 2011
Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan.
The effects of polychlorinated biphenyls (PCBs) on liver function and their differences between sexes were analyzed in Japanese medaka (Oryzias latipes) exposed to PCB126 or Kanechlor-400 (KC-400) using microarray. PCB exposure induced vitellogenin 1 expression in female medaka while suppressing choriogenin genes, which suggests that the effects of PCBs on estrogen-responsive genes do not occur directly through an estrogen receptor-mediated pathway. Reduction of androgen receptor alpha expression was also observed, and the gene expression pattern in PCB-exposed males changed to become more similar to that of females.
View Article and Find Full Text PDFAlteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126.
Mar Pollut Bull
October 2008
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Polychlorinated biphenyls (PCBs) are known as neurotoxic chemicals and possibly alter animal behavior. We previously reported that PCB-exposure induced abnormal schooling behavior in Japanese medaka (Oryzias latipes). This abnormal behavior might be caused by the functional alteration of central or terminal nervous system.
View Article and Find Full Text PDF[Effect of PCBs on insulin sensitivity in rats].
Fukuoka Igaku Zasshi
May 1995
Department of Community Health Science, Saga Medical School.
Insulin sensitivity was assessed by euglycemic insulin clamp method in the rats given Kanechlor (KC)-400 for 1 to 12 weeks. As a result, insulin sensitivity was depressed increasingly with period of administration of KC-400. Increases in total cholesterol, HDL-C, triglyceride, lipid peroxide and T3 in blood plasma were also observed in the experimental rats.
View Article and Find Full Text PDFMetabolic activation by several forms of purified cytochrome P-450 of aflatoxin B1 to a product(s) mutagenic to Salmonella typhimurium TA100 was examined. Of the 5 forms of cytochrome P-450 purified from liver microsomes of untreated and PCB-treated male rats, a constitutive form purified from untreated male rats, P-450-male, and a high-spin form of cytochrome P-450, P-448-H, from PCB-treated rats were highly active.
View Article and Find Full Text PDFSerum and hepatic cholesterol content in rats treated with polychlorinated biphenyls (PCBs, KC-400) were increased compared to those of control rats. This increase of cholesterol content was reduced to control level by simultaneous administration of ethyl p-chlorophenoxyisobutyrate (CPIB). Also, when lecithin-cholesterol acyltransferase (LCAT) (EC.
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