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Combinatory Effect of Pequi Oil ()-Based Nanoemulsions Associated to Docetaxel and Anacardic Acid () in Triple-Negative Breast Cancer Cells In Vitro.
Pharmaceutics
September 2024
Laboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Campus Universitário-Centro Metropolitano, Ceilandia Sul, Brasilia 72220-275, Brazil.
Combination therapy integrated with nanotechnology offers a promising alternative for breast cancer treatment. The inclusion of pequi oil, anacardic acid (AA), and docetaxel (DTX) in a nanoemulsion can amplify the antitumor effects of each molecule while reducing adverse effects. Therefore, the study aims to develop pequi oil-based nanoemulsions (PeNE) containing DTX (PDTX) or AA (PAA) and to evaluate their cytotoxicity against triple-negative breast cancer cells (4T1) in vitro.
View Article and Find Full Text PDFTRPML1 ameliorates seizures-related neuronal injury by regulating autophagy and lysosomal biogenesis via Ca/TFEB signaling pathway.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, Zhengzhou 450052, Henan Province, PR China. Electronic address:
Alterations in autophagy have been observed in epilepsy, although their exact etiopathogenesis remains elusive. Transient Receptor Potential Mucolipin Protein 1 (TRPML1) is an ion channel protein that regulates autophagy and lysosome biogenesis. To explore the role of TRPML1 in seizures-induced neuronal injury and the potential mechanisms involved, an hyperexcitable neuronal model induced by Mg-free solution was used for the study.
View Article and Find Full Text PDFDiscovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175.
J Am Chem Soc
August 2024
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
TMEM175 is a lysosomal potassium and proton channel that is associated with the development of Parkinson's disease. Advances in understanding the physiological roles of TMEM175 have been hampered by the absence of selective inhibitors, and studies involving genetic perturbations have yielded conflicting results. Here, we report the discovery and characterization of the first reported TMEM175-selective inhibitors, 2-phenylpyridin-4-ylamine (2-PPA), and AP-6.
View Article and Find Full Text PDFPlasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels.
Proc Natl Acad Sci U S A
August 2024
Department of Biochemistry, Structural Bioinformatics and Computational Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Two-pore channels are pathophysiologically important Na- and Ca-permeable channels expressed in lysosomes and other acidic organelles. Unlike most other ion channels, their permeability is malleable and ligand-tuned such that when gated by the signaling lipid PI(3,5)P, they are more Na-selective than when gated by the Ca mobilizing messenger nicotinic acid adenine dinucleotide phosphate. However, the structural basis that underlies such plasticity and single-channel behavior more generally remains poorly understood.
View Article and Find Full Text PDFGene therapy targeting the blood-brain barrier.
Vitam Horm
July 2024
Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany; DZHK (German Research Centre for Cardiovascular Research), Hamburg-Lübeck-Kiel, Germany. Electronic address:
Article Synopsis
- Endothelial cells create the blood-brain barrier (BBB), which protects the brain but makes it hard for some medicines to get in.
- Scientists are trying different ways to help treatments get across the BBB, like attaching drugs to special molecules that the barrier recognizes.
- Another idea is to make the drugs right inside the endothelial cells, since those cells are connected to the blood and can deliver the medicines directly to the brain.
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