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Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning.
J Immunotoxicol
April 2015
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki , Japan and.
The Yusho poisoning incident, caused by rice oil contaminated with polychlorinated biphenyls (PCBs), polychlorinated quarterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) generated by heat-denatured PCBs, occurred in 1968 in western Japan. Although severe symptoms are rarely observed today, the levels of PCBs and PCDFs in the sera of Yusho patients remain high. The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity.
View Article and Find Full Text PDFAssociation of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event.
Environ Health
October 2008
Department of Planning Information and Management, The University of Tokyo Hospital, Tokyo, Japan.
Background: The Yusho poisoning incident, which was caused by rice bran oil contaminated with polychlorinated biphenyls (PCBs), polychlorinated quarterphenyls (PCQs) and polychlorinated dibenzofurans (PCDFs) generated by heat denaturation of PCB, occurred in 1968 in western Japan. Annual physical, dermatological, dental, ophthalmological and laboratory examinations were conducted for Yusho patients after the incident. From 2001, blood levels of individual PCDF congeners were also measured.
View Article and Find Full Text PDF[Elevation of serum creatine kinase and low serum aldolase in the patients with KANEMI YUSHOU].
Fukuoka Igaku Zasshi
May 2003
School of Health Sciences, Nagasaki University, Nagasaki 852-8520.
We studied the rates of the patient with the elevation of serum creatine kinase using the routine medical checkup data from KANEMI YUSHOU patients between 1995 and 2001. We also studied the serum aldolase level and light microscopic observation of muscle tissue in rats during strenuous exercise given the polychlolinated biphenyls. Fifteen percent of the patients showed the elevation of serum creatine kinase.
View Article and Find Full Text PDFHealth risks to infants from exposure to PCBs, PCDDs and PCDFs.
Food Addit Contam
April 2000
Bureau of Chemical Safety, Banting Research Centre, Health Canada, Ottawa, Ontario, Canada.
Global contamination by a variety of anthropogenic persistent organic chemicals, such as dioxins and PCBs, has resulted in human exposure throughout all phases of development. Detectable concentrations of PCBs and dioxins have been found in amniotic fluid, placenta and foetal tissue samples while infants who are breast-fed can obtain blood levels greater than those of their mother's. In two separate food poisoning episodes where infants were exposed in utero to elevated levels of heat-degraded PCBs (PCBs, PCQs, PCDFs), a variety of adverse mental and physical developmental abnormalities have been observed.
View Article and Find Full Text PDFBlood polychlorinated biphenyls and manifestation of symptoms in chronic "Yusho" patients.
Fukuoka Igaku Zasshi
May 1995
Department of Public Health, Faculty of Medicine, Kyushu University 60, Fukuoka.
The correlation between blood PCB concentration and clinical manifestation of symptoms was investigated in 259 chronic "Yusho" patients, using the information obtained from the nationwide health examination conducted in 1988, twenty years after the outbreak. Concentrations of blood PCBs ranged 0.6-32.
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