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A Clinical Practice-Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin.
Pharmacol Res Perspect
February 2025
Department of Internal Medicine, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
To understand differences in anti-factor-Xa levels produced by two different dosing strategies (conventional and individualized) for therapeutic enoxaparin in a cohort of hospital inpatients. A multicenter, retrospective cohort study over a two- and a half-year period for inpatients with stable renal function and on therapeutic enoxaparin. Anti-factor-Xa levels were taken 3-5 h after enoxaparin administration and a minimum of 48 h of dosing.
View Article and Find Full Text PDFFundamentals of intervertebral disc degeneration and related discogenic pain.
World J Orthop
January 2025
Department of Orthopedics, The Third Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing 100039, China.
Lumbar intervertebral disc degeneration is thought to be the main cause of low back pain, although the mechanisms by which it occurs and leads to pain remain unclear. In healthy adult discs, vessels and nerves are present only in the outer layer of the annulus fibrosus and in the bony endplate. Animal models, and histological and biomechanical studies have shown that annulus tear or endplate injury is the initiating factor for painful disc degeneration.
View Article and Find Full Text PDFImmediate Stentless Lacrimal Sac to Conjunctiva Reconstructive Ostomy for Cancer and Trauma Defects: LACROS (Conjunctivodacryocystostomy).
Ophthalmic Plast Reconstr Surg
January 2025
Plastic Surgery Unit, Clínica San Francisco, Tuluá, Colombia.
Purpose: To describe and evaluate the efficacy and safety of lacrimal sac to conjunctiva reconstructive ostomy for proximal lacrimal system reconstruction.
Methods: This retrospective study included 41 patients (32 cancer and 9 trauma; 36 primary and 5 secondary) who underwent lacrimal sac to conjunctiva reconstructive ostomy. The technique involves creating a direct connection between a surgical opening in the lacrimal sac, which maintains its bony attachments to prevent ostomy occlusion, and the medial conjunctiva (medial fornix, bulbar, and palpebral).
Anatomy of the distal tendinous structure of the triceps brachii: implications for the role of the triceps brachii to resist valgus elbow forces during baseball pitching.
J Shoulder Elbow Surg
January 2025
Department of Clinical Anatomy, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
Background: Biomechanical studies suggest that the triceps brachii muscle generates resistive force against valgus stress on the elbow during baseball pitching. However, given the parallel fiber orientation in the distal tendinous structure of the triceps brachii, the mechanism behind this anti-valgus force remains unclear. In the present study, we aimed to examine the anatomy of the distal tendinous structure of the triceps brachii using bony morphological, macroscopic, and histological methods.
View Article and Find Full Text PDFBackground: It is generally accepted that the greater palatine nerve and artery supply the palatal mucosa, gingiva, and glands, but not the bone or tooth adjacent to those tissues. When the bony palate is observed closely, multiple small foramina are seen on the palatal surface of the alveolar process. The authors hypothesized that the greater palatine nerve and artery might supply the maxillary teeth via the foramina on the palatal surface of the alveolar process and the superior alveolar nerve and artery.
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