AI Article Synopsis
- In mammalian cells, the interphase centriole develops a primary cilium during the cell cycle, which may serve sensory functions.
- Despite sensory roles for primary cilia being unproven, research shows that growth factors and calcium ionophore can trigger calcium changes and shrinkage in these cilia.
- This leads to the hypothesis that primary cilia may play a role in calcium fluxes essential for stimulating growth in mammalian cells.
Article Abstract
In every mammalian cell the interphase centriole forms a primary cilium during some part of the cell cycle. Many sensory receptors are modifications of primary cilia, but a sensory role for primary cilia in mammalian cells has not been proven. Nevertheless, we have found that both growth factors and calcium ionophore (A23187) induce calcium fluxes and shortening of the primary cilium. This evidence raises the question of whether the primary cilium is involved in calcium fluxes that are necessary for growth stimulation in mammalian cells.
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