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Anti-NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review.
Int J Gynaecol Obstet
November 2024
Women's Health Center, Vinmec Times City Hospital, Hanoi, Vietnam.
Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra-limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti-NMDA (N-methyl-D-aspartate) receptor encephalitis was first described in 2007 and has become one of the most commonly recognized autoimmune encephalitides. The disease is predominantly female (81%) and affects young patients (37% <18 years old, 95% <45 years old), with up to 58% of women over 18 years old having ovarian teratoma.
View Article and Find Full Text PDFEffects of concentric and eccentric exercise regimens on bioenergetic efficiency of lymphocytes in sedentary males.
Eur J Sport Sci
December 2024
Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Medical College, Chang Gung University, Taoyuan, Taiwan.
Article Synopsis
- Eccentric exercise training (EET) is shown to enhance physical performance with lower metabolic strain compared to concentric exercise training (CET), but its impact on bioenergetic efficiency in peripheral blood mononuclear cells (PBMCs) is not well understood.
- In a study involving 33 sedentary males, participants were assigned to either EET, CET, or a control group, with both exercise groups demonstrating improved aerobic fitness and physiological responses post-intervention.
- Both EET and CET increased beneficial T cell types and mitochondrial functions in PBMCs, suggesting that EET may offer similar benefits to CET while eliciting a lower cardiovascular response.
Prevalence and risk surveillance of anti-mitochondrial antibody-positive myositis: Outcomes of a nationwide survey.
J Neurol Sci
December 2024
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address:
Article Synopsis
- Anti-mitochondrial antibody (AMA)-positive myositis is a chronic muscle disease linked to serious cardiac issues and breathing difficulties, with a prevalence of 0.3 cases per 100,000 people in Japan.
- The study analyzed data from 380 patients over ten years, revealing high rates of cardiac complications (53%) and respiratory impairment (33%), alongside significant risks such as recurrence (29%) and need for mechanical support (respirators in 22% and cardiac devices in 32%).
- Key risk factors for worse outcomes included abnormal echocardiograms, respiratory issues, and muscle biopsy results, highlighting the need for proactive management strategies to address potential severe complications.
Article Synopsis
- Extreme heat from climate change is linked to a rise in infectious diseases and heat-related health issues, making it crucial to understand how heat, inflammation, and disease interact.
- In neonates, the TRPV1 channel, sensitive to heat and inflammation, affects breathing and may make them more prone to seizures during heat stress.
- Research on neonatal rats showed that inflammation from LPS lowers seizure thresholds during heat stress; blocking TRPV1 reduced seizure risk and improved breathing efficiency, indicating that inflammation worsens respiratory issues and seizure susceptibility through TRPV1 in vagus neurons.
Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge.
Front Physiol
February 2024
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.
Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules and regulates acetylation of tubulin and other proteins. The possibility that HDAC6 participates in hypoxic signaling is supported by evidence that 1) hypoxic gas challenges cause microtubule depolymerization, 2) expression of hypoxia inducible factor alpha (HIF-1α) is regulated by microtubule alterations in response to hypoxia, and 3) inhibition of HDAC6 prevents HIF-1α expression and protects tissue from hypoxic/ischemic insults.
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