Pregnant Mice were stimulated with two substances, an antibronchitic lysate (LAB) and diethyldithiocarbamate (DTC). PFC response was studied in mothers and their offspring for 6 weeks after birth. An increase in PFC response was noted in the immunostimulated adult Mice. In the newborn Mice, the number of PFC increased between the 1st and 6th week. In comparison with controls, PFC response appeared later in the newborns to LAB-stimulated mothers and earlier in those to DTC-stimulated mothers.

Download full-text PDF

Source

Publication Analysis

Top Keywords

pfc response
12
pfc
5
[study transfer
4
transfer immunostimulation
4
immunostimulation mother
4
mother young
4
young mouse
4
mouse immunostimulants
4
immunostimulants pfc
4
pfc test]
4

Similar Publications

Generalized learning is a fundamental process observed across species, contexts, and sensory modalities that enables animals to use past experiences to adapt to changing conditions. Evidence suggests that the prefrontal cortex (PFC) extracts general features of an experience that can be used across multiple situations. The anterior cingulate cortex (ACC), a region of the PFC, is implicated in generalized fear responses to novel contexts.

View Article and Find Full Text PDF

Chronic stress profoundly affects the structure and function of the prefrontal cortex (PFC), a brain region critical for executive functions and emotional regulation. This review synthesizes current knowledge on stress-induced PFC plasticity, encompassing structural, functional, and molecular changes. We examine how chronic stress leads to dendritic atrophy, spine loss, and alterations in neuronal connectivity within the PFC, particularly affecting the medial PFC.

View Article and Find Full Text PDF

Characterization of serum and brain cytokine levels following prolonged binge-like methamphetamine self-administration and cued methamphetamine seeking.

J Neuroimmunol

January 2025

Department of Psychology, Arizona State University, Tempe, AZ 85257, USA; Interdisciplinary Graduate Program in Neuroscience, School of Life Sciences, Arizona State University, Tempe, AZ 85257, USA. Electronic address:

Methamphetamine (METH) use is associated with peripheral and brain inflammation that can contribute to METH-associated toxicity and heightened cue reactivity. However, the persistence of these phenomena, especially with regards to changes in brain proinflammatory cytokine levels, is not yet clear. In this study, we determined the effects of repeated binge-like METH self-administration (96-h/week for 3 weeks) followed by cued drug seeking for up to 60 days into abstinence in male and female rats.

View Article and Find Full Text PDF

Hypertension is not merely a vascular disorder but a significant risk factor for neural impairment. Moreover, healthcare for the hypertensive population with environmental or occupational pollutants has become an issue of increasing concern in public health. As a traditional neurotoxic heavy metal, Pb exposure results in neuroinflammation as well as neurodegenerative diseases.

View Article and Find Full Text PDF

Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. We performed single cell-electrophysiology combined with morphological reconstructions on layer 6 (L6) excitatory neurons in the medial PFC (mPFC) of wild type (WT) rats, rats carrying the human coding polymorphism rs16969968 in Chrna5 and α5 knockout (KO) rats.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!