AI Article Synopsis
- In a study involving 25 patients with homozygous beta thalassemia and 7 with the trait, serum levels of IgG, IgM, and IgA were found to be elevated in those with homozygous beta thalassemia, particularly after undergoing splenectomy.
- Homozygous beta thalassemia patients showed impaired serum opsonic activity against Salmonella typhi and staphylococci, with additional impairment observed against salmonella post-splenectomy.
- Phagocytic activity against both bacteria was reduced in beta thalassemia patients, and splenectomy further decreased the effectiveness against salmonella, while those with the thalassemia trait showed immune responses
Article Abstract
Serum IgG, IgM and IgA were determined in 25 patients with homozygous beta thalassemia and 7 with the trait. The levels were increased in homozygous patients and increased further after splenectomy. Serum opsonic activity against Salmonella typhi and staphylococci was impaired in homozygous patients. Splenectomy caused more impairment against salmonella only. Similarly, phagocytic power against both organisms was lower in beta thalassemia. Further decrease against salmonella occurred after splenectomy. Patients with thalassemia trait did not differ from normal controls.
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| http://dx.doi.org/10.1159/000206875 | DOI Listing |
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