AI Article Synopsis
- 7-Methylguanine is the primary product formed when dimethylnitrosamine (DMNA) interacts with nucleic acids in living organisms, identifiable after strong acid treatment.
- Enzymatic and alkaline hydrolysis of nucleic acids effectively releases methylamine.
- The methylamine extracted from the nucleic acids of rats treated with 15N-DMNA has a molecular weight of 31, indicating that the nitrogen in DMNA does not participate in the binding process.
Article Abstract
7-Methylguanine is the main compound resulting from in vivo interaction between dimethylnitrosamine (DMNA) and nucleic acids, detected after strong acid hydrolysis. However, enzymic and alkaline hydrolysis of nucleic acids leads to quantitative liberation of methylamine. Methylamine isolated from liver nucleic acids of 15N-DMNA-treated rats has molecular weight of 31, thus demonstrating that DMNA-nitrogen is not involved in the binding.
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