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Prevalence of Salmonella and Shigella species and their multidrug resistance patterns among pediatric populations in Ethiopia: a systematic review and meta-analysis.
BMC Infect Dis
January 2025
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, P.O. Box: 1145, Ethiopia.
Background: Salmonella and Shigella are major enteric pathogens that cause diarrhea in children worldwide. They are pathogenic microbes that cause significant diarrheal morbidity and mortality in under five children in resource limited countries. Thus, this systemic review and meta-analysis aimed to investigate the prevalence of Salmonella and Shigella species and their multidrug resistance patterns in pediatric populations in Ethiopia.
View Article and Find Full Text PDFSexually transmitted shigellosis.
Acta Dermatovenerol Alp Pannonica Adriat
December 2024
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Shigellae can be transmitted through sexual contact, especially among gay, bisexual, and other men who have sex with men (gbMSM). The dynamics and factors contributing to sexual transmission of shigellosis are not yet fully understood. Shigella spp.
View Article and Find Full Text PDFA Recombinant Strain Expressing ETEC Heat-Labile Enterotoxin B Subunit Shows Promise for Vaccine Development via OMVs.
Int J Mol Sci
November 2024
Department of Microbiology and Parasitology, Navarra Medical Research Institute (IdiSNA), University of Navarra, 31008 Pamplona, Spain.
Diarrheal diseases caused by and enterotoxigenic (ETEC) are significant health burdens, especially in resource-limited regions with high child mortality. In response to the lack of licensed vaccines and rising antibiotic resistance for these pathogens, this study developed a recombinant strain with the novel incorporation of the gene for the heat-labile enterotoxin B (LTB) subunit of ETEC directly into 's genome, enhancing stability and consistent production. This approach combines the immunogenic potential of LTB with the antigen delivery properties of outer membrane vesicles (OMVs), aiming to provide cross-protection against both bacterial pathogens in a stable, non-replicating vaccine platform.
View Article and Find Full Text PDFArticle Synopsis
- * Resistance rates for key antibiotics were significant, with 36.67% for cefotaxime, 21.67% for ciprofloxacin, and 10.00% for azithromycin; additionally, 23.33% of the strains produced extended-spectrum beta-lactamases (ESBLs).
- * The study highlighted the genetic basis of resistance, identifying specific resistance genes and plasmids, and demonstrated
Immunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration.
Iran J Allergy Asthma Immunol
July 2024
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
As the most common cause of bacillary dysentery or shigellosis, Shigella sonnei (S nonnei) has spread throughout the world. Invasion of the colorectal epithelial cells by this facultative intracellular bacterium occurs via various virulence factors. The increase in the resistance rate highlights the need for novel interventions, particularly increasing the urgency of the development of Shigella vaccines that may offer an effective solution.
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