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Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Purpose: Corneal alkali burns are severe ocular injuries characterized by intense inflammation, tissue damage, and vision impairment, with current treatments often insufficient in restoring corneal function and clarity. This study aimed to evaluate the therapeutic effects of recombinant thrombomodulin domain 1 (rTMD1) in the treatment of corneal alkali burns, focusing on its impact on inflammation, tissue repair, fibrosis, and neovascularization.
Methods: A murine model of corneal alkali burn was utilized to investigate the therapeutic potential of rTMD1.
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Alzheimers Dement
December 2024
Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Background: White matter hyperintensities (WMH) were reported to contribute to the thinning of regional cortex connected to WMH in cerebral small vessel disease. However, the relationship between WMH and regional changes in WMH-connected cortex in Alzheimer's disease (AD) remains unclear. The objective of this study is to investigate the association between WMH and regional cortical thickness, amyloid and tau deposition, and synaptic density changes in the WMH-connected cortex.
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Alzheimers Dement
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Background: Factors contributing to cognitive decline in adults include vascular risk factors (hypertension, hyperlipidemia, diabetes), lower education, age, Apolipoprotein E4(ApoE4) and cerebral hypoperfusion. The interplay between aging and vascular processes disrupts cerebral hemodynamics, heightening the risk of cognitive impairment and neurological disorders. Similarly, ApoE4 gene increases the risk of vascular-related cognitive impairment and small vessel disease.
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Alzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Alzheimer's disease (AD) has been known for more than a century, but its complex pathophysiology remains unclear. Previous studies have been suggesting a potential role of neuroinflammation and cerebral vascular changes in AD progression. Part of the immune response relies on the role of Vascular Cell Adhesion Molecule (VCAM) in cell transit through the endothelium.
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Alzheimers Dement
December 2024
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Background: COVID-19, identified as the greatest health concern of the century, is associated with vascular inflammation and endothelial activation, resulting in multisystemic damage, including to the central nervous system (CNS). Recent investigations indicate a link between endothelial dysfunction, neurological changes, and the development of the so-called long-COVID. Molecules expressed in the endothelium such as P-selectin, E-selectin, and VEGF-A, increased under inflammatory injury, may be associated with conditions like brain injuries and neurodegenerative diseases.
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