Cryostat sections of adult and fetal tissues of the rat and human were investigated by a double immunoperoxidase technique for the presence of three developmentally-regulated mouse antigens, TEC-1,2,3. In the adult rats the TEC-1 antigen was detected on the epithelium of the isthmic portion of the oviduct, in some kidney tubuli, and in the brain; the TEC-2 antigen was distributed on the epithelium of various tissues, but it was also present on cells that may correspond to phagocytizing macrophages; the TEC-3 antigen was detected on endothelia of some vessels or capillaries. In rat fetuses only the TEC-1 antigen was detected; it was found on digestive tract epithelium and some kidney tubuli. In adult human tissues the distribution of TEC-1 antigen resembled that known for SSEA-1; the TEC-2 antigen was detected in some kidney tubules. In human midpregnancy fetuses the TEC-1 antigen was found in the same tissues as in adults; TEC-2 was detected in the thyroid gland. There was no staining of adult or fetal human tissues with TEC-03 antibody. The data show different patterns of expression of TEC-1,2,3 antigens among the species studied.
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