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Case: A 60-year-old right-hand-dominant woman experienced progressive enlargement of a mass over the index distal interphalangeal (DIP) joint over 5 years, leading to joint destruction and swan neck deformity. Radiography showed arthritis, erosion, and calcific deposition. Surgical intervention included mass excision, synovectomy, and DIP joint arthrodesis.
View Article and Find Full Text PDF3D Mechanical Response Stem Cell Complex Repairs Spinal Cord Injury by Promoting Neurogenesis and Regulating Tissue Homeostasis.
Adv Healthc Mater
January 2025
Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Spinal cord injury (SCI) leads to acute tissue damage that disrupts the microenvironmental homeostasis of the spinal cord, inhibiting cell survival and function, and thereby undermining treatment efficacy. Traditional stem cell therapies have limited success in SCI, due to the difficulties in maintaining cell survival and inducing sustained differentiation into neural lineages. A new solution may arise from controlling the fate of stem cells by creating an appropriate mechanical microenvironment.
View Article and Find Full Text PDFOptimizing orthobiologic therapies with exercise, diet, and supplements.
PM R
January 2025
Department of Orthopaedic Surgery, Stanford University, Redwood City, California, USA.
Orthobiologic injections including platelet-rich plasma (PRP) and cell-based injections are becoming increasingly popular. Evidence suggests that these therapies can be effective in certain situations. The efficacy of these injections may be more dependent on the quality of the injectate, which given their autologous nature, may be dependent on lifestyle choices like exercise, diet, and supplements.
View Article and Find Full Text PDFPreventing confounding in observational studies in orthopedic trauma surgery through expert panels: a systematic review.
Eur J Trauma Emerg Surg
January 2025
Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
Purpose: Confounding in observational studies can be mitigated by selecting only those patients, in whom equipoise of both treatments is secured by experts' disagreement over optimal therapy.
Methods: We conducted a systematic review to identify observational studies in the field of orthopedic trauma surgery that utilized expert panels for patient inclusion in order to limit the potential for confounding.
Results: Four studies were identified that used expert panels to select participants based on expert disagreement.
Curative and preemptive treatment of amputee pain by targeted muscle reinnervation: experience from a French military trauma center.
Eur J Trauma Emerg Surg
January 2025
Department of Orthopedic, Trauma and Reconstructive Surgery, Percy Military Hospital, 101 Avenue Henri Barbusse, Clamart, 92140, France.
Introduction: Targeted muscle reinnervation (TMR) is a technique that has proven effective for the treatment and prevention of chronic pain following amputation, though its adoption remains limited. The authors report on their initial experience using TMR.
Methods: A prospective study was conducted in a military trauma center involving traumatic amputees treated with either curative or preemptive TMR.
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