Emil Starkenstein 1884-1942. The life and work of a German pharmacologist.

Naunyn Schmiedebergs Arch Pharmacol

Published: December 1984

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http://dx.doi.org/10.1007/BF00512057DOI Listing

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Emil Starkenstein (1884-1942), professor of pharmacology at the German Medical Faculty of Charles University in Prague, was not only an experimental pharmacologist, but also the pioneer of clinical pharmacology. During the World War I (1914-1918) he took advantage of his knowledge of experimental pharmacology for the new approaches to the treatment of bacillary dysentery, cholera and of epidemic typhus fever. In 1918 he published the article "Clinical Pharmacology--Theory and Praxis at the Patient's Bedside", in which he defined the main task of clinical pharmacology as the implementation and verification of experimental pharmacology achievements in clinical therapy.

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Emil Starkenstein's paper (1910) on the influence of chloride on the enzymatic activity of liver amylase has been considered generally as the first experimental demonstration of the biospecific adsorption of an enzyme on a solid substrate. Emil Starkenstein's life is also briefly mentioned.

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