Paleoserological investigations make possible "biological reconstruction" of old populations and comparison of their characteristics with corresponding characteristics of contemporary population on the same area. The work presents results of the investigation of ABO system blood group distribution from the following archaeological locations: Vlasac (5000 B. C., Mesolithic), Gamzigrad (near Zajecar, III-IV era A. D., Roman period), Vinca (near Grocka, IX era A. D.) and Ras (near N. Pazar, IX-XI era A. D.). At the same time the work presents distribution of ABO blood groups among present population on the same area.
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