[Correlation between maternal glycohemoglobin values and insulin secretion in children of diabetic mothers].

Monthly determination of glycohaemoglobins from the 5th month until delivery were determined in a group of diabetic pregnant women, and insuline and peptide-C levels were measured in their newborns. Women with pathological babies had higher glycohaemoglobin values at the end of gestation (8.92 +/- 1.9) than those with normal babies (6.47 +/- 1.02) and those in control group (6.37 +/- 0.76). The number of abnormal glycohaemoglobin levels in successive gestational months was significantly higher in the group with neonatal pathology. The peptide-C and insuline concentrations were higher in pathological newborn (6.37 +/- 9,3 ng/ml and 80 +/- 102 mcU/ml) than in normal babies (0.65 +/- +/- 0.53 ng/ml and 16.5 +/- 10.6 mcU/ml). A correlation between peptide-C concentration in newborns and levels of glycohaemoglobins in their mothers (p less than 0.05) was found. Authors conclude that monthly determination of glycohaemoglobin during gestation is a good index of metabolic control in the mother, and consequently useful in order to predict fetal pathology.