[Local immune and inhibitor protection in patients with newly detected destructive pulmonary tuberculosis complicated by nonspecific endobronchitis].

The authors studied the level of secretory Ig, activity of elastase and locally produced acid-resistant inhibitors (ARI) of proteinases in 63 new cases of destructive pulmonary tuberculosis complicated by nonspecific endobronchitis. Functional abnormality of the local defense systems (immune and inhibitory) was found in patients with purulent bronchial inflammation associated with a considerable rise of granulocyte proteinase content. This makes it necessary to carry out corrective drug therapy of these alterations. A significant positive correlation was revealed between SIgA concentration and ARI in catarrhal patterns of endobronchitis.