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pH-Independent Selective Formation of VO Motif Incorporating a Family of Hydrazone Ligands: Synthesis, Structure, and Luminescence-Based Sensing Studies toward Selective Metal Ions.
Inorg Chem
November 2024
Department of Chemistry, Jadavpur University, Jadavpur, Kolkata, West Bengal 700 032, India.
Two new dioxidovanadium(V) compounds with the general formula [VO(L)] (L = hydrazone ligand) were synthesized using three different methods (acidic, neutral, and basic media) with either VOSO. 5HO, [VO(acac)], or NHVO as the starting material and hydrazone ligands. In both cases, five coordinated V ions adopted distorted square pyramidal geometry through the coordination of two oxido ligands and one hydrazone ligand.
View Article and Find Full Text PDFLactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
ChemMedChem
December 2024
Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.
The emergence of resistance against current antimalarial treatments has necessitated the need for the development of novel antimalarial chemotypes. Toward this goal, we recently optimised the antimalarial activity of the dihydroquinazolinone scaffold and showed it targeted PfATP4. Here, we deconstruct the lactam moiety of the tricyclic dihydroquinazolinone scaffold and investigate the structure-activity relationship of the truncated scaffold.
View Article and Find Full Text PDFReusing Peptide Spectral Reference Libraries to Discover Putative Plasma Biomarkers of Response to Cancer Chemotherapy.
Methods Mol Biol
July 2024
Bowel Cancer & Biomarker Laboratory, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, St Leonards, NSW, Australia.
Biofluids such as blood plasma are rich reservoirs of potential biomarkers for disease diagnosis, prognosis, and prediction of treatment response. However, mass spectrometry analysis of circulating plasma proteins remains challenging. The introduction of data-independent acquisition mass spectrometry (DIA-MS) is an important step toward addressing detection of less abundant plasma proteins.
View Article and Find Full Text PDFALTering Cancer by Triggering Telomere Replication Stress through the Stabilization of Promoter G-Quadruplex in .
ACS Chem Biol
July 2024
Department of Biophysics, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091 West Bengal, India.
Most of the human cancers are dependent on telomerase to extend the telomeres. But ∼10% of all cancers use a telomerase-independent, homologous recombination mediated pathway called alternative lengthening of telomeres (ALT). Due to the poor prognosis, ALT status is not being considered yet in the diagnosis of cancer.
View Article and Find Full Text PDFEnabling Health Information Recommendation Using Crowdsourced Refinement in Web-Based Health Information Applications: User-Centered Design Approach and EndoZone Informatics Case Study.
JMIR Hum Factors
May 2024
College of Medicine and Public Health, Flinders University, Clovelly Park, Australia.
Background: In the digital age, search engines and social media platforms are primary sources for health information, yet their commercial interests-focused algorithms often prioritize irrelevant content. Web-based health applications by reputable sources offer a solution to circumvent these biased algorithms. Despite this advantage, there remains a significant gap in research on the effective integration of content-ranking algorithms within these specialized health applications to ensure the delivery of personalized and relevant health information.
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