The level of pituitary hormones (somatotropin and prolactin) and pancreatic hormones (insulin and glucagon) was measured by radioimmunoassay in blood of patients with insulin-independent diabetes mellitus with and without diabetic microangiopathies, in the state of decompensation and during treatment. Forty-four patients aged 26 to 60 years were examined. Some patients with insulin-independent diabetes with and without diabetic microangiopathies demonstrated an elevation of blood insulin and glucagon. The blood somatotropin level was found to be increased in patients with insulin-independent diabetes mellitus with diabetic microangiopathies in the state of decompensation. No correlations were established between prolactin and insulin levels, somatotropin and insulin levels in the blood of patients with insulin-independent diabetes mellitus. During treatment, one could see a decrease in the somatotropin content and a tendency toward elevation in the insulin content and reduction in the glucagon level in patients with insulin-independent diabetes with diabetic microangiopathies.
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