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A common marker of affect recognition dysfunction in the FTD spectrum of disorders.
Eur J Neurol
January 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Article Synopsis
- Poor affect recognition is an early indicator of frontotemporal dementia (FTD), and this study used the Comprehensive Affect Testing System (CATS-A) to assess emotional dysfunction in FTD patients compared to healthy controls.
- The study involved 139 FTD patients of various subtypes and tested them alongside 116 healthy controls, measuring their Affective Recognition Quotient (ARQ) to evaluate emotional recognition accuracy.
- Results showed that the CATS-A effectively differentiated between FTD patients and healthy controls with high accuracy (AUC 0.89) and had robust internal reliability, suggesting it's a valuable clinical tool for assessing emotional dysfunction in FTD.
Optimization of divalent mercury removal from synthetic wastewater using desirability function in central composite design of response surface methodology.
J Environ Health Sci Eng
June 2024
School of Materials, Energy, Water, Environmental Sciences and Engineering (MEWES), The Nelson Mandela African Institution of Science and Technology (NM-AIST), P.O. Box 447, Arusha, Tanzania.
Unlabelled: Heavy metals exist in the ecosystem both naturally and due to anthropogenic activities and as recalcitrant pollutants; they are non-biodegradable and cause acute and chronic diseases to human beings and many lifeforms. A statistical experimental approach was applied in this current study to optimize the detoxification of mercury [Hg(II)] from mono-component biosorption system by a novel hybrid granular activated carbon (biosorbent) prepared from maize plant residues. The analysis of variance by the application of central composite design shows that all the studied independent factors greatly influence Hg(II) removal efficiency and uptake capacity.
View Article and Find Full Text PDFA reactive oxygen species-triggerable theranostic prodrug system.
J Control Release
December 2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China. Electronic address:
Abnormally elevated levels of reactive oxygen species (ROS) are considered one of the characteristics of tumors and have been extensively employed in the construction of tumor-activated prodrugs. However, ideal ROS-activated molecular triggers that possess high sensitivity and easy functionalization for tailoring specific prodrugs, remain scarce. In this work, we developed a highly reactive oxygen species (hROS, such as •OH, ONOO and HOCl)-responsive molecular trigger (namely FDROS-4) through the conjunction of methylene blue (MB) and 2, 6-bis (hydroxymethyl) aniline via urea bond, integrating imaging and therapeutic functions.
View Article and Find Full Text PDFThe CNIC polypill (Acetylsalicylic acid + Atorvastatin + Rampril) in secondary prevention of cardiovascular disease in patients with type 2 diabetes: A comparative analysis with alternative therapeutic approaches.
Int J Cardiol
January 2025
Cardiology Department, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain; Cardiology Department, Hospital Universitario de San Juan, Alicante, Spain.
Background: Patients with type 2 DM (T2DM) and established cardiovascular disease (CVD) are at high risk of recurrent CV events. We analysed the use of the CNIC-polypill (acetylsalicylic acid, ramipril, and atorvastatin) compared with other therapeutic strategies in patients with T2DM and CVD from the retrospective NEPTUNO study.
Methods: Patients were stratified into four therapeutic approaches: CNIC-polypill, its monocomponents as loose medications, equipotent medications, and other therapies.
The clinical value of nonpharmacological interventions for preventing postoperative delirium: a narrative review.
Minerva Anestesiol
September 2024
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China -
Postoperative delirium (POD) is a prevalent perioperative complication among elderly individuals and is a cause of significant detrimental consequences for both individuals and society. Pharmacological and nonpharmacological prevention methods/therapies have been proposed to mitigate the risk of POD. Nevertheless, the efficacy of pharmacological interventions is controversial, and some of them cause side effects.
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