Using a radioimmunoassay a low C-peptide fasting level was revealed in children, pregnant and lying-in women as well as in patients with insulin-dependent diabetes mellitus. After breakfast and insulin administration with curative purposes the IRI concentration in children increased whereas the C-peptide level changed insignificantly. Changes of the insulin secretion were more noticeable in severe diabetes mellitus with vascular complications and in disease decompensation. The atherogenic nature of the lipid metabolism (an increase in the cholesterol, triglyceride and beta-lipoprotein levels), changes in the liver and a tendency to vascular involvement are the results of insulin effect inadequacy. Such metabolic derangements in pregnant women create unfavorable conditions for the development of fetus and may lead to early atherogenic processes.
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