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Blood pressure targets, medication considerations and special concerns in elderly hypertension III: Focus on stroke and neurodegenerative disorders.
J Formos Med Assoc
January 2025
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Controlling hypertension has become an important issue in the elderly population in whom neurological comorbidities are highly prevalent. Most of the large-scale trials focusing on hypertension management in older populations have excluded patients with comorbid neurological disorders. However, this population requires special considerations, as the benefits of antihypertensive agents are mostly uncertain and there is a higher risk of adverse events.
View Article and Find Full Text PDFBeyond the Score: Exploring the Associations Between Adverse Childhood Experiences and Electrophysiological Responses to Errors.
Stress Health
February 2025
Psychology Department, Mount St. Vincent University, Halifax, Canada.
Adverse childhood experiences (ACEs) have diverse effects on physical development and mental health. This study aimed to clarify the relationship between the quantity of ACE exposure, type of ACE exposure, and subjective level of stress felt, correlated with event-related potential activity across the scalp, while controlling for relevant confounding variables. Fifty-three participants aged 18-32 years completed questionnaires assessing their current mental health, self-regulation, childhood socioeconomic status, and history of traumatic events.
View Article and Find Full Text PDFThe evolution of the Amber additive protein force field: History, current status, and future.
J Chem Phys
January 2025
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Molecular dynamics simulations are pivotal in elucidating the intricate properties of biological molecules. Nonetheless, the reliability of their outcomes hinges on the precision of the molecular force field utilized. In this perspective, we present a comprehensive review of the developmental trajectory of the Amber additive protein force field, delving into researchers' persistent quest for higher precision force fields and the prevailing challenges.
View Article and Find Full Text PDFNineteenth-century land use shapes the current occurrence of some plant species, but weakly affects the richness and total composition of Central European grasslands.
Landsc Ecol
January 2025
Department of Spatial Sciences, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha - Suchdol, Czech Republic.
Context: Historical land use is thought to have influenced plant community diversity, composition and function through the local persistence of taxa that reflect ecological conditions of the past.
Objectives: We tested for the effects of historical land use on contemporary plant species richness, composition, and ecological preferences in the grassland vegetation of Central Europe.
Methods: We analyzed 6975 vegetation plots sampled between 1946 and 2021 in dry, mesic, and wet grasslands in the borderland between Austria, the Czech Republic, and Slovakia.
Surgical management of dysphagia due to diffuse idiopathic skeletal hyperostosis: the role of barium swallow fluoroscopy-a case report.
J Spine Surg
December 2024
Spine Clinic, Elsan Jean Villar Private Hospital, Bordeaux, France.
Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition that might lead to dysphagia because of massive osteophytes that may be present at multiple levels. Confirming the symptomatic level to guide surgical management and avoid extensive surgery is important, however, there is no globally accepted consensus on the topic.
Case Description: We report the case of a 51-year-old man, with no specific past medical history, who has been complaining of a 3-months pain in the left side of the tongue base with sensation of a lump in the throat and dysphagia.
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