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Increased Oxidative and Nitrative Stress and Decreased Sex Steroid Relaxation in a Vitamin D-Deficient Hyperandrogenic Rodent Model-And a Validation of the Polycystic Ovary Syndrome Model.
Nutrients
January 2025
Department of Obstetrics and Gynaecology, Semmelweis University, Üllői Street 78/a, 1082 Budapest, Hungary.
Background/objectives: Both hyperandrogenism (HA) and vitamin D deficiency (VDD) can separately lead to impaired vascular reactivity and ovulatory dysfunction in fertile females. The aim was to examine the early interactions of these states in a rat model of PCOS.
Methods: Four-week-old adolescent female rats were divided into four groups: vitamin D (VD)-supplemented ( = 12); VD-supplemented and testosterone-treated ( = 12); VDD- ( = 11) and VDD-and-testosterone-treated ( = 11).
Synthesis, HS releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5'-dithioacetates.
Sci Rep
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Hydrogen sulfide (HS) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-HS-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5'-Dithioacetate derivatives were synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine and thymidine), and the putative 5'-thio metabolites were also produced from uridine and adenosine.
View Article and Find Full Text PDF[Sarolta Steinberger, MD (1875-1966) and the presumption of innocence].
Orv Hetil
January 2025
2 Széchenyi István Egyetem, Deák Ferenc Állam- és Jogtudományi Kar Győr, Áldozat utca 12., 9026 Magyarország.
Different Breeding Values Under Uniform Environmental Condition for Milk Production Yield Traits in Holstein-Friesian Cows.
Animals (Basel)
December 2024
Department of Animal Sciences, Albert Kázmér Faculty of Agriculture and Food Sciences, Széchenyi István University, Vár t. 2, H-9200 Mosonmagyaróvár, Hungary.
In this study, 1,616,549 Holstein-Friesian females were genotyped for genomic evaluation of genetic merit (BV). Genotyping was performed using the EuroGenomics MD v3.0 chipset on the Illumina microarray scanner platform operated by an accredited Illumina laboratory.
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