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LE cell phenomenon: nuclear IgG deposits inhibit enzymatic cleavage of the nucleus of damaged cells and support its phagocytic clearance by PMN.
Biomed Pharmacother
April 2004
Department of Radiology, University of Bonn, Sigmund-Freud Strasse 25, 53105 Bonn, Germany.
Apoptotic cell death, phagocytic uptake, and their interplay may induce/trigger autoantibody production and autoimmunity. Herein the role of immunoglobulin G (IgG) anti-dsDNA autoantibodies in nucleo-phagocytosis by polymorpho-nuclear cells (PMN) has been analyzed. Necrotaxis, phagocytosis and PMN with engulfed nuclei can be imaged by vital microscopy.
View Article and Find Full Text PDFBy the word necrotaxis is understood a collection of phenomena provoked by sudden cell death, or more exactly by the agony of a cell killed by the experimenter (Bessis, 1963). Recent work has followed three approaches: the role of the cytoplasm, and of anucleated fragments; the role of calcium; and the study of the direction or orientation of movement, by biophysical methods. Numerous questions remain unanswered: the presence or absence of relationship with immune phenomena and the comparison of necrotaxis and apoptosis.
View Article and Find Full Text PDFA particular form of chemotaxis: necrotaxis. An historical view.
Blood Cells
November 1993
Centre Européen d'Histoire de la Médecine, Université Louis Pasteur de Strasbourg, France.
Necrotaxis has been defined as chemotaxis toward a dying cell. Chemotaxis, since its discovery in 1888, has been the subject of controversy, both as to its reality and as to an appropriate definition such as directional movement induced by chemical stimuli. Microcinematography has settled both questions.
View Article and Find Full Text PDF[Necrotaxis. Importance of its study in pathology and pharmacology].
Bull Acad Natl Med
November 1984
The name "necrotaxis" has been given to a special type of chemotaxis in which granulocytes and monocytes are attracted to cells in the process of dying. Microirradiation devices (conventional UV and laser) have been used to destroy a target cell. Immediately, leukocytes (neutrophils and monocytes) can be seen to advance towards the damaged cell and to engulf it.
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