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Bypass of Methoxyamine-Adducted Abasic Sites by Eukaryotic Translesion DNA Polymerases.
Int J Mol Sci
January 2025
Siberian Branch of the Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
The apurinic/apyrimidinic site (AP site) is a highly mutagenic and cytotoxic DNA lesion. Normally, AP sites are removed from DNA by base excision repair (BER). Methoxyamine (MOX), a BER inhibitor currently under clinical trials as a tumor sensitizer, forms adducts with AP sites (AP-MOX) resistant to the key BER enzyme, AP endonuclease.
View Article and Find Full Text PDFEnhancing Industrial Hemp () Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications.
Int J Mol Sci
January 2025
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, Italy.
The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports sustainable development goals by reducing reliance on synthetic chemicals in healthcare. biomass, in particular, has emerged as a valuable resource within this context. This study focuses on the hydroethanolic extract of leaves (CSE), which exhibited significant levels of phenolic compounds contributing to robust antioxidant activity.
View Article and Find Full Text PDFThe transgenic MutaMouse hepatocyte mutation assay in vitro: Mutagenicity and mutation spectra of six substances with different mutagenic mechanisms.
Mutat Res Genet Toxicol Environ Mutagen
January 2025
Free University of Berlin, Institute of Pharmacy, Pharmacology and Toxicology, Berlin, Germany; BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany.
Mutagenicity testing is a component of the hazard assessment of industrial chemicals, biocides, and pesticides. Mutations induced by test substances can be detected by in vitro and in vivo methods that have been adopted as OECD Test Guidelines. One of these in vivo methods is the Transgenic Rodent Assay (TGRA), OECD test guideline no.
View Article and Find Full Text PDFTrends in pretreatment and determination methods for furfurals in foods: Update since 2017.
Food Res Int
February 2025
Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:
Background: Furfurals, key derivatives of Maillard reactions commonly found in everyday foods, have been identified as having significant toxic effects on human health. Excessive intake of furfurals can lead symptoms such as weight loss, poor nutrient metabolism which followed by disease occurrence. The severe carcinogenicity, mutagenicity and genotoxicity of furfurals were well recognized recently.
View Article and Find Full Text PDFAlkylated DNA repair by a novel HhH-GPD family protein from Crenarchaea.
Nucleic Acids Res
January 2025
College of Plant Protection, Agricultural University of Hebei, No. 2596 Lekai South Street, Baoding City, Lianchi District, Hebei Province 071001, China.
HhH-GPD (helix-hairpin-helix-glycine/proline/aspartate) family proteins are involved in DNA damage repair. Currently, mechanism of alkylated DNA repair in Crenarchaea has not been fully clarified. The hyperthermophilic model crenarchaeon Saccharolobus islandicus REY15A possesses a novel HhH-GPD family protein (Sis-HhH-GPD), where its Ser152 corresponds to a conserved catalytic Asp in other HhH-GPD homologs.
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