The results are presented of studying the response of the foot skin blood microcirculatory vessels after injecting 2ml of saline solution of NaCl into the hip. A group of patients with diabetes mellitus aggravated by angiopathy of low extremities was managed with insulin during 4 to 18 years and examined versus insulin-untreated diabetes mellitus patients, persons with low limb obliterating thromboangiitis and healthy volunteers. The studies were carried out, using the "skin window" method, which allows one to investigate not only the capillary function but also the state of other skin microcirculatory units. It was determined that at rest the functioning microvessel density per the tissue area unit is compensatory enhanced in patients with angiopathy. The pain irritating effect (the injection) is integrated into a stereotypic vasospastic response in all the persons under study, becoming pathologically persistent in patients with angiopathy. It was concluded that the maximum tissue sparing is necessary during the injection therapy, considering this procedure as a factor of arising and developing the vessel affection, especially in diabetes mellitus insulin-treated patients, subjecting to systematic insulin injections.
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