Serial biopsies during the first 24 hours after dinitrochlorobenzene (DNCB) challenge in fifteen sensitized patients have shown that DNCB associates with Langerhans cells within I hour of application, and has reached the dermis around the appendages by 6 hours.

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http://dx.doi.org/10.1111/j.1365-2133.1984.tb04697.xDOI Listing

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